Review Article
Exploring Advances in Early Screening of Nasopharyngeal Carcinoma Based on Regional Medical Big Data Platforms
Guowen Zhan*
Issue:
Volume 14, Issue 1, February 2026
Pages:
1-14
Received:
8 January 2026
Accepted:
20 January 2026
Published:
31 January 2026
Abstract: Nasopharyngeal carcinoma (NPC) has an insidious onset and lacks obvious early symptoms, often leading to diagnosis at middle or late stages and significantly worsening patient prognosis. Regional medical big data platforms integrate clinical, genomic, and imaging data sources. These platforms provide advanced technical support and novel research perspectives, such as the identification of new biomarkers and predictive modeling approaches, to facilitate early detection of NPC. This review summarizes recent advances in NPC early detection enabled by these platforms. It highlights the application and benefits of multimodal screening strategies, including Epstein-Barr virus (EBV)-related biomarker assays, DNA methylation analysis, imaging screening techniques, and machine learning algorithms. We synthesize the latest research findings and analyze the potential of multi-omics data integration and artificial intelligence technologies to improve screening accuracy. Moreover, we discuss how these approaches can reduce false-positive findings in NPC early detection. We also explore future directions for achieving precise and personalized NPC early detection through big data platforms. This review aims to provide both theoretical foundations and practical guidance for building regional medical big data platforms, thereby facilitating the optimization and wider implementation of NPC early detection systems by enhancing data integration and analytical capabilities.
Abstract: Nasopharyngeal carcinoma (NPC) has an insidious onset and lacks obvious early symptoms, often leading to diagnosis at middle or late stages and significantly worsening patient prognosis. Regional medical big data platforms integrate clinical, genomic, and imaging data sources. These platforms provide advanced technical support and novel research pe...
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Research Article
Anti-inflammatory Effects of Soluble Eggshell Membrane Powder on LPS-Stimulated Caco-2 Cells: Modulation of Proinflammatory Cytokine Gene Expression
Javier Moran*
Issue:
Volume 14, Issue 1, February 2026
Pages:
15-19
Received:
5 March 2026
Accepted:
14 March 2026
Published:
26 March 2026
DOI:
10.11648/j.ajcem.20261401.12
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Abstract: Maintaining intestinal epithelial barrier integrity is essential for mucosal homeostasis and immune defense. Bioactive compounds derived from natural sources have attracted interest for their potential to modulate inflammatory responses in the gut. Eggshell membrane, a proteinaceous layer rich in collagen, glycosaminoglycans (including hyaluronic acid and chondroitin sulfate), and bioactive peptides, has demonstrated anti-inflammatory properties in preclinical and clinical settings, although its effects on intestinal inflammatory markers remain largely unexplored. The aim of this study was to evaluate the anti-inflammatory effects of soluble eggshell membrane powder on lipopolysaccharide (LPS)-induced inflammatory gene expression in human intestinal epithelial Caco-2 cells. Cells were pre-stimulated with LPS (50 µg/mL) for 1 h, then co-treated with the eggshell membrane product at concentrations of 0.01% and 0.1% in the continued presence of LPS for an additional 3 h. Gene expression of TNFα, IL1α, IL1β, IL6, and IL10 was quantified by qRT-PCR (n = 4) using the 2−ΔΔCt method and analyzed by one-way ANOVA with Dunnett's post hoc test. Treatment at 0.01% significantly reduced TNFα expression by 55.1 ± 16.7% (p < 0.05), IL1α by 86.5 ± 12.0% (p < 0.0001), and IL1β by 64.3 ± 15.2% (p < 0.01), relative to LPS-only controls, corresponding to 99.0%, 126.9%, and 129.2% attenuation of the LPS-induced increases, respectively. At 0.1%, IL1α was also significantly reduced (−56.9 ± 11.1%, p < 0.01), while an inverse dose–response pattern was observed for TNFα and IL1β. IL6 expression was not reduced by treatment and showed a significant increase at 0.1%. IL10 was not significantly affected by either LPS or treatment. The MTT assay confirmed that the product did not affect cell viability at any concentration tested (0.001–0.1%). These results suggest that soluble eggshell membrane powder exerts selective anti-inflammatory activity targeting early NF-κB/TLR4-dependent proinflammatory mediators, and may have potential applications in intestinal health management.
Abstract: Maintaining intestinal epithelial barrier integrity is essential for mucosal homeostasis and immune defense. Bioactive compounds derived from natural sources have attracted interest for their potential to modulate inflammatory responses in the gut. Eggshell membrane, a proteinaceous layer rich in collagen, glycosaminoglycans (including hyaluronic a...
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